Now that it has been possible to solve all the issues of my Duo4kSE with the help of this forum, there is still one annoying problem with my (non SE) Duo4k setup:
After a while picture and audio always drift apart more and more. I found out that pressing the "red button" in the audio menu (toggling between Downmix and Passthrough) immediately syncs picture and audio.
But after a while it has drifted apart noticeably again.
Is there an old config spooking around? Do I need to make a new full installation without backup?